Bruce Mazer

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I love working with children and their families because children are amazing; sick or well they are always sunny and positive!

Hospital information

Academic appointments

Professor of Pediatrics and associate member, Division of Experimental Medicine, Department of Medicine, McGill University

Associate Chair of Research, Department of Pediatrics

Other appointments

Chairman, Grants Committee, Canadian Allergy, Asthma and Immunology Foundation

Education

University

Columbia University Jewish Theological Seminary of America

Medical Degree

McGill University

Residency

Pediatrics, Montreal Children’s Hospital, McGill University

Fellowship(s)

Pediatric Allergy and Immunology, National Jewish Health Center, Univesrity of Colorado, Denver, CO

Fun fact about me

I play guitar and sing, and I love to travel.

Research

Research interests

Asthma and food allergies affect almost 20% of children in North America. These diseases are important causes of morbidity and mortality, and have a huge economic and social impact. My laboratory uses a combination of human studies and animal modeling to determine new ways of changing the immune response to allergens, and to help to naturally shape immune tolerance in individuals with allergies and asthma.

Research foci

  • Modulation of immune responses with intravenous immune globulin;
  • Dissection of regulatory B-cell responses in allergy;
  • Understanding T- and B-cell cross-talk through novel approaches to immune synapse formation;
  • Antigen processing by dendritic cells;
  • Production and modification of immunoglobulin in humans and mice;
  • How IgG acts as a bridge between innate and adaptive immunity.

Keywords

Asthma, food allergy, immune therapies, intravenous immunoglobulin, B-lymphocytes and mucosal responses, antigen presentation, IgE, IVIg, semaphorins

Awards and distinctions

2010 Immunology Research Award from the Canadian Society of Allergy and Clinical Immunology

2006-2011 Chercheur national from the Fonds de recherche du Québec–Santé

External website

http://meakins.mcgill.ca/mazer.php

Related Articles

March 2011: Demystifying allergies and immune reactions 

April 2011: Patients: The motivation behind clinical research; three MCH clinical researchers share their experiences 

April 2011: There’s no life like it: MCH physician researchers share the joy of their dual calling

Selected publications

Massoud AH, Yona M, Xue D, Chouiali F, Alturaihi H, Ablona A, Mourad W, Piccirillo CA, Mazer BD. Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J Allergy Clin Immunol. 2013 Nov 7. pii: S0091-6749(13)01476-0. doi: 10.1016/j.jaci.2013.09.029. [Epub ahead of print]

Massoud AH, Guay J, Shalaby KH, Bjur E, Ablona A, Chan D, Nouhi Y, McCusker CT, Mourad MW, Piccirillo CA, Mazer BD. Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3-positive regulatory T cells. J Allergy Clin Immunol. 2012 Jun; 129(6):1656-1665.e3. Epub 2012 May 5.

Kaufman GN, Massoud AH, Audusseau S, Banville-Langelier AA, Wang Y, Guay J, Garellek JA, Mourad W, Piccirillo CA, McCusker C, Mazer BD. Intravenous immunoglobulin attenuates airway hyperresponsiveness in a murine model of allergic asthma. Clin Exp Allergy 2011 May; 41(5):718-28. doi: 10.1111/j.1365-2222.2010.03663.x. Epub 2011 Jan 24.

Vazquez-Tello A, Halwani R, Li R, Nadigel J, Bar-Or A, Mazer BD, Eidelman DH, Al-Muhsen S, Hamid Q. IL-17A and IL-17F expression in B lymphocytes. Int Arch Allergy Immunol. 2012; 157(4):406-16. Epub 2011 Nov 25.

Drolet JP, Frangie H, Guay J, Hajoui O, Hamid Q, Mazer BD. B lymphocytes in inflammatory airway diseases. Clin Exp Allergy 40(6):841-9, 2010 [Review].